Thiophenes as phenyl bio-isosteres: Application in radiopharmaceutical design—I. Dopamine uptake antagonists
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چکیده
منابع مشابه
Thiophenes as phenyl bio-isosteres: application in radiopharmaceutical design--I. Dopamine uptake antagonists.
Possible applications of thiophenes in radiopharmaceutical chemistry have been explored. Thiophene for benzene ring substitution was applied to the synthesis of thienyl-[18F]GBR 13119, an analog of the potent and selective dopamine uptake inhibitor [18F]GBR 13119. In vivo regional brain distribution in mice shows essentially identical results for the thienyl and phenyl compounds (striatum/cereb...
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ژورنال
عنوان ژورنال: International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology
سال: 1989
ISSN: 0883-2897
DOI: 10.1016/0883-2897(89)90138-4